Introduction The loss of retinal neurons

2018-10-20

Introduction The loss of retinal neurons, their connections and supporting glia in ocular degenerative diseases causes permanent blindness, principally because lost photoreceptors and retinal ganglion cells (RGCs) are not replaced and RGC aniracetam fail to regenerate (Berry et al., 2008). Clinica

tranylcypromine br Materials and methods br Verification and

2018-10-20

Materials and methods Verification and authentication Resource details Materials and methods Verification and authentication Resource details. Materials and methods Resource details: Materials and methods Verification and authentication Ethics/consents: Ethics approval for

br Resource table Resource details The

2018-10-20

Resource table. Resource details The gene encoding the complement receptor 1 (CR1) was identified to be a risk gene for Alzheimer\'s disease (AD) in genome-wide association studies (Lambert et al., 2009). Subsequently, we demonstrated that a coding copy number variation (CNV) in CR1 could explai

The Sonic Hedgehog SHH pathway is active in the

2018-10-20

The Sonic Hedgehog (SHH) pathway is active in the adult SEZ, where it has been proposed to regulate cell proliferation (Ruat et al., 2012; Ahn and Joyner, 2005; Machold et al., 2003) and to modulate the migration of neuroblasts exiting the niche (Angot et al., 2008). The mosaic inactivation of the S

Several nonintegrative reprogramming strategies including Se

2018-10-20

Several nonintegrative reprogramming strategies including Sendai virus (Fusaki et al., 2009) and episomal plasmids (Okita et al., 2011, 2013; Yu et al., 2009) have been tested to produce safe, transplantable iPSCs. Yet, recent whole-genome sequencing studies have failed to demonstrate a reduction in

br Experimental Procedures br Acknowledgments br Introductio

2018-10-20

Experimental Procedures Acknowledgments Introduction Type II alveolar epithelial cells (AECs) are a major cellular component of the distal lung epithelium, where they secrete pulmonary surfactant and generate type I AECs that cover most of the surface area of the prostaglandin e (Whitsett

Cip Kip proteins are expressed at higher levels in HSCs

2018-10-20

Cip/Kip proteins are expressed at higher levels in HSCs than in progenitor cells (Passegué et al., 2005). The role of p21Cip1 in HSCs is restricted to cell cycle regulation under stress conditions (van Os et al., 2007). p27Kip1 deficiency does not affect HSC numbers or HSC self-renewal, but alters t

In this study we verify

2018-10-20

In this study, we verify the hypothesis if TRIM28 plays a role in reprogramming of mouse embryonic fibroblasts into iPS cells. We stably silenced the expression of Trim28 in MEFs and submitted them to the reprogramming process by infection with lentiviral vector carrying the expression of Yamanaka f

Until now only a handful of

2018-10-20

Until now, only a handful of studies have investigated the role of the SAC in mammalian stem cells. When Mad2 is deleted in the murine epidermal lineage, interfollicular epidermal urat1 inhibitor sustain growth; in contrast, hair follicular bulge stem cells fail to grow (Foijer et al., 2013). Haplo

A recently developed gene editing technology using

2018-10-20

A recently developed gene-editing technology using RNA-guided endonuclease (Gaj et al., 2013), which allows the desired gene to be inserted into a genomic safe harbor (GSH) area (Papapetrou et al., 2011), should be considered to avoid undesirable random genomic insertion of EOS-C(3+)-KR in the gener

br Results Our previous work showed

2018-10-20

Results Our previous work showed that severe bacterial sepsis induced by P. aeruginosa or by its LPS causes a TLR4-dependent dysfunctional expansion of HSC and hematopoietic progenitor interleukin 2 receptor (HSPC) (Rodriguez et al., 2009). To determine whether these changes are MYD88 or TRIF de

br Results To investigate the molecular and

2018-10-20

Results To investigate the molecular and cellular phenotypes perturbed in DS, we compared DS and normal ESCs and their neural derivatives. In the past, we have isolated three DS-ESC lines, namely CSES13, CSES20, and CSES21, from PGS-derived embryos with trisomy of chromosome 21 (Figure 1A) (Bianc

In the present study we aimed to establish a combination

2018-10-20

In the present study, we aimed to establish a combination therapy approach composed of cellular replacement by ESC-derived neural progenitors linked to BDNF supply. For this reason, we have generated BDNF-overexpressing mouse ESCs by knockin technology that display an enhanced neuronal and GABAergic

Accumulating evidence has demonstrated that cancer

2018-10-20

Accumulating evidence has demonstrated that cancer cells are able to activate the autologous complement system (Cho et al., 2014; Fishelson, 2003; Matsumoto et al., 1997; Niculescu et al., 1992). To evade complement destruction, tumor cells upregulate mCRPs, and CD59 is the most relevant among the t

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2018-07-29