• Co culture of CDSCs with USSCs revealed regulation of osteo

  2018-10-22

  

  Co-culture of CDSCs with USSCs revealed regulation of osteo- and chondro-associated markers, from which BMP2, BMP4, PTHLH, ACAN and FOXF1 were upregulated and BSP, RUNX2, SOX9, TWIST1 and MSX2 were downregulated after co-culture (Supplementary Fig. 8). Many different transcription factors and regula

• br Materials and methods br Results br Discussion Recent neu

  2018-10-20

  

  Materials and methods Results Discussion Recent neurogenesis studies and the discovery of multipotent neural stem chk1 derived from the adult mammalian CNS, including that of humans, have had a considerable influence on potential treatments for neural injury (Gross, 2000; Ming and Song, 20

• Wnt-C59 br Human arteriogensis and angiogenesis As

  2018-10-20

  

  Human arteriogensis and angiogenesis As in the mouse, the limited human data available strongly support the paradigm that remodeling and Wnt-C59 of pre-existing vascular interconnections (arteriogenesis) is the primary mechanism responsible for providing a new vascular supply in human cardiovasc

• br Introduction Somatic cells can

  2018-10-20

  

  Introduction Somatic vegf inhibitor can be reprogrammed into induced pluripotent stem cells (iPSCs) by the transduction of four embryonic transcriptional factors (Takahashi et al., 2007b; Takahashi and Yamanaka, 2006; Yu et al., 2007). This discovery provides not only a novel opportunity for reg

• br Source of funding This work was

  2018-10-20

  

  Source of funding This work was supported by research funding from The Ministry of Education, Culture, Sports, Science and Technology Grant-in-Aid for Scientific Research (C) (22591555) and the Riken Center for Developmental Biology Collaborative Research Fund, Kobe (08001475). Disclosures

• Introduction The loss of retinal neurons

  2018-10-20

  

  Introduction The loss of retinal neurons, their connections and supporting glia in ocular degenerative diseases causes permanent blindness, principally because lost photoreceptors and retinal ganglion cells (RGCs) are not replaced and RGC aniracetam fail to regenerate (Berry et al., 2008). Clinica

• tranylcypromine br Materials and methods br Verification and

  2018-10-20

  

  Materials and methods Verification and authentication Resource details Materials and methods Verification and authentication Resource details. Materials and methods Resource details: Materials and methods Verification and authentication Ethics/consents: Ethics approval for

• br Resource table Resource details The

  2018-10-20

  

  Resource table. Resource details The gene encoding the complement receptor 1 (CR1) was identified to be a risk gene for Alzheimer\'s disease (AD) in genome-wide association studies (Lambert et al., 2009). Subsequently, we demonstrated that a coding copy number variation (CNV) in CR1 could explai

• The Sonic Hedgehog SHH pathway is active in the

  2018-10-20

  

  The Sonic Hedgehog (SHH) pathway is active in the adult SEZ, where it has been proposed to regulate cell proliferation (Ruat et al., 2012; Ahn and Joyner, 2005; Machold et al., 2003) and to modulate the migration of neuroblasts exiting the niche (Angot et al., 2008). The mosaic inactivation of the S

• Several nonintegrative reprogramming strategies including Se

  2018-10-20

  

  Several nonintegrative reprogramming strategies including Sendai virus (Fusaki et al., 2009) and episomal plasmids (Okita et al., 2011, 2013; Yu et al., 2009) have been tested to produce safe, transplantable iPSCs. Yet, recent whole-genome sequencing studies have failed to demonstrate a reduction in

• br Experimental Procedures br Acknowledgments br Introductio

  2018-10-20

  

  Experimental Procedures Acknowledgments Introduction Type II alveolar epithelial cells (AECs) are a major cellular component of the distal lung epithelium, where they secrete pulmonary surfactant and generate type I AECs that cover most of the surface area of the prostaglandin e (Whitsett

• Cip Kip proteins are expressed at higher levels in HSCs

  2018-10-20

  

  Cip/Kip proteins are expressed at higher levels in HSCs than in progenitor cells (Passegué et al., 2005). The role of p21Cip1 in HSCs is restricted to cell cycle regulation under stress conditions (van Os et al., 2007). p27Kip1 deficiency does not affect HSC numbers or HSC self-renewal, but alters t

• In this study we verify

  2018-10-20

  

  In this study, we verify the hypothesis if TRIM28 plays a role in reprogramming of mouse embryonic fibroblasts into iPS cells. We stably silenced the expression of Trim28 in MEFs and submitted them to the reprogramming process by infection with lentiviral vector carrying the expression of Yamanaka f

• Until now only a handful of

  2018-10-20

  

  Until now, only a handful of studies have investigated the role of the SAC in mammalian stem cells. When Mad2 is deleted in the murine epidermal lineage, interfollicular epidermal urat1 inhibitor sustain growth; in contrast, hair follicular bulge stem cells fail to grow (Foijer et al., 2013). Haplo

• A recently developed gene editing technology using

  2018-10-20

  

  A recently developed gene-editing technology using RNA-guided endonuclease (Gaj et al., 2013), which allows the desired gene to be inserted into a genomic safe harbor (GSH) area (Papapetrou et al., 2011), should be considered to avoid undesirable random genomic insertion of EOS-C(3+)-KR in the gener

16325 records 1088/1089 page Previous Next First page 上5页 1086108710881089