• Clinically a number of observations indicate that PES may

  2018-10-30

  

  Clinically, a number of observations indicate that PES may have functional implications beyond the eye (Bettis et al., 2014; Katsi et al., 2013; Tarkkanen et al., 2008), although opinion is divided with regards to its significance (Andrikopoulos et al., 2014; Gonen et al., 2013; Hietanen et al., 200

• Current therapies for the treatment of HPV infection

  2018-10-30

  

  Current therapies for the treatment of HPV infection of the ano-genital tract are mainly ablative and devoted to the removal of damaged HPV-infected lesions, such as warts and squamous intraepithelial lesions (Krogh von et al., 2000). However, most patients are not featured by macroscopic lesions. I

• enkephalin We acknowledge some limitations in our study Firs

  2018-10-30

  

  We acknowledge some limitations in our study. First, misclassification of SCLC or COPD has to be considered since our study included diverse countries in which different diagnostic criteria may apply. A pathology comparability analysis was performed by Stang et al. in a German case series; the agree

• br Results br Discussion Our study confirmed the safety and

  2018-10-30

  

  Results Discussion Our study confirmed the safety and tolerability of highly pure VEDT (99%) at doses up to five times greater than those given to patients in previous studies, which used a mixture of tocotrienols (Rahmat et al., 1993; Qureshi et al., 1995, 2002; Zaiden et al., 2010). The rela

• In the study by a

  2018-10-30

  

  In the study by , a significant correlation between the amount of ctDNA and serum hCG was found in patients with GTN and detectable ctDNA by genotyping. However, the exact relationship between circulating tumor DNA and serum hCG remains to be elucidated in future studies. Such studies may need to co

• Elevated sCD may indicate an increased immunological capacit

  2018-10-30

  

  Elevated sCD30 may indicate an increased immunological capacity to react against foreign HLA antigens. Due to contact with bioincompatible dialysis membranes and exposure to HLA or HLA-cross-reactive infectious agents (D\'Orsogna et al., 2011), end-stage renal disease patients exhibit alterations i

• Mechanistically we show that CRL CDT is the primary target

  2018-10-30

  

  Mechanistically, we show that CRL4CDT2 is the primary target of inactivation by pevonedistat in melanoma and that its toxicity is dependent primarily on the stabilization of the CRL4CDT2 substrates SET8 and p21 both in vitro and in vivo. The lack of a therapeutic response on melanoma cells with hypo

• A major question which arises from

  2018-10-29

  

  A major question which arises from the aforementioned work is if activation of a DDR within telomere repeats indicates physical DNA double stranded breaks or is merely changes in chromatin without an associated lesion. Recently, a new method has been developed which allows the accurate detection of

• Competencia es de inversi n e innovaci n estrat

  2018-10-29

  

  Competencia es de inversión e innovación estratégica. En el caso de Gruma esta es la forma de competencia dominante, la empresa ha invertido en general en desarrollar su escala y capacidad productiva, así como en su diversificación. Su estrategia de expansión ha seguido una senda de: 1. Crecimiento

• br Data In order to inform the

  2018-10-29

  

  Data In order to inform the SPIDIA-DNA EQA participants on the quality of the extracted DNA from blood a dedicated report was realized [1,4]. The report contains the evaluation of the performance of the specific laboratory and the overall distribution of the participants’ data for each gDNA quali

• Data experimental design materials and methods br Conflict o

  2018-10-29

  

  Data, experimental design, materials and methods Conflict of interest Acknowledgements We would like to acknowledge the BBSRC for support (grant BB/H001948/1), the Chemical Analysis Facility at the University of Reading for access to the Orbitrap instrument, the Centre for Advanced Microscopy

• Experimental design materials and methods br Acknowledgments

  2018-10-29

  

  Experimental design, materials and methods Acknowledgments This work was financially supported by the Academy of Finland [grants #253269, #272424, # 307335 and #273870] and Tekes [grant #40128/14]. The Biocenter Finland and the Proteomics Facility of the Turku Centre for Biotechnology are acknow

• br Experimental design materials and

  2018-10-29

  

  Experimental design, materials and methods For the potential oral administration, the six experimental liquid formulations of commercial pine-derived phytosterol (CPP) reduced pH to 2 and increased pH again up to 7 to mimic the human digestive system (Yi et al., 2016) [1]. The concentration of β-

• A second negativity that has been elicited from deviant stim

  2018-10-29

  

  A second negativity that hcv protease inhibitor has been elicited from deviant stimuli in passive auditory oddball experiments is late discriminative negativity (LDN). This negative component appears after MMN and peaks at approximately 400–430ms in response to changes in speech stimuli for both ch

• On the one hand it is

  2018-10-29

  

  On the one hand, it is unsurprising that the enos inhibitor has not been investigated as a source of susceptibility. First, research guided by neurobiological susceptibility models tends to group individuals by susceptibility markers, categorize environments as high vs. low on a valenced dimension

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