• There are a large number of

  2018-10-25

  

  There are a large number of reticulated pigmentations that need to be distinguished, including dyskeratosis congenita (DKC), X-linked reticulate pigmentary disorder (XLRPD), Naegeli-Franceschetti-Jadassohn syndrome (NFJS), dermatopathia pigmentosa reticularis (DPR), DDD, reticulate acropigmentation

• The amelanotic melanoma represents of

  2018-10-25

  

  The amelanotic melanoma represents 2–8% of all melanomas. These melanomas have a unique appearance and present a great diagnostic challenge to dermatologists. In addition, the prevalence rate of melanoma is lower in Asians, and the most common subtype is acral lentiginous melanoma. Our patient prese

• A selective maintenance model incorporating economic depende

  2018-10-25

  

  A selective maintenance model incorporating economic dependence was recently presented by Dao et al. [27,28]. Time and cost savings are achieved when several components are simultaneously repaired in a selective maintenance strategy. The authors considered two types of time and cost savings in mult

• cumpli a os en Despu s del n mero Marta

  2018-10-25

  

  cumplió 25 años en 2014. Después del número 50, Marta Lamas, su fundadora y directora hasta ese momento, había decidido concluir el ciclo de la revista. No obstante, conscientes de la enorme importancia del proyecto y del reconocimiento que había logrado tanto en México como en Latinoamérica, las in

• br Myocardial regeneration after allogeneic stem cell therap

  2018-10-24

  

  Myocardial regeneration after allogeneic stem cell therapy Moreover, as outlined above, a consensus is gaining ground that most of the favourable effects of cell transplantation protocols used until now exert their beneficial effect by a paracrine mechanism of the transplanted TAK-875 over the s

• MSCs can express several WNT ligands Cho

  2018-10-24

  

  MSCs can express several WNT ligands (Cho et al., 2006; Etheridge et al., 2004). This endogenous WNT signaling may play a negligible role in MSC expansion, because we found no significant effects on cell proliferation or subsequent differentiation when endogenous WNT proteins were prevented. However

• ibmx However before application in a clinical

  2018-10-24

  

  However before application in a clinical context, a number of issues still need to be considered. Indeed, SSC transplantation in cancer patients requires techniques to exclude cancer cell contamination, because implantation of as few as 20 leukemic ibmx can result in cancer relapse (Jahnukainen et

• Cancer cells use epigenetic mechanisms to control

  2018-10-24

  

  Cancer 5-aminolevulinic acid use epigenetic mechanisms to control tumor growth, invasion, and resistance to therapy. Novel therapeutic approaches targeting epigenetic modifications are considered the new frontier in cancer therapy. In fact, pharmacological modulation of epigenetic alterations is ex

• Cryopreserved peripheral blood mononuclear cells PBMC from t

  2018-10-24

  

  Cryopreserved peripheral blood mononuclear cells (PBMC) from this patient were used for the generation of an induced pluripotent stem cell (iPSC) that harbour a “highest risk” RET mutation according to ATA guidelines, i.e. a 2753T>C missense de novo mutation at exon 16 leading to the most frequent

• In previous tumor studies we have

  2018-10-24

  

  In previous tumor studies, we have used a p53-null syngeneic mouse model to mimic p53 loss of function in human breast cancer. This model was developed by transplanting p53-null mammary epithelium into the cleared mammary fat pads of wild-type, syngeneic Balb/c-recipient mice, resulting in spontaneo

• CSCs of breast tumors are commonly enriched by combinations

  2018-10-24

  

  CSCs of breast tumors are commonly enriched by combinations of several cell-surface antigens, such as CD44/CD24/EPCAM (Al-Hajj et al., 2003), or by high ALDH (aldehyde dehydrogenase) activity (Ginestier et al., 2007). However, existing markers lack specificity, also reflective of a substantial propo

• In order to understand how hematopoiesis

  2018-10-24

  

  In order to understand how hematopoiesis is regulated, it is necessary not only to understand the different signals emanating from the niche (Anthony and Link, 2014), but also to comprehend the integration of these signals by HSCs. Canonical Wnt signaling has been related to the regulation of HSCs

• Zscan is sometimes considered as

  2018-10-24

  

  Zscan4 is sometimes considered as a marker of highly pluripotent status, merely due to its expression at the two-cell stage during development (Cerulo et al., 2014). However, based on our observation, we would like to propose that the expression of Zscan4 is activated in response to telomere shorten

• eukaryotic initiation factor br Results br Discussion In the

  2018-10-24

  

  Results Discussion In the meibomian gland, low numbers of LRCs were observed after 28, 42, and 56 days of chase, which fulfill the slow-cycling, undifferentiated, and low population criteria of adult epithelial stem eukaryotic initiation factor characterized in other tissues (Alonso and Fuchs

• Mitochondria are highly dynamic organelles

  2018-10-24

  

  Mitochondria are highly dynamic organelles with complex structures involved in multiple processes, including energy metabolism, reactive oxygen species (ROS) generation, mitochondrial dynamics and distribution, and the induction of apoptosis. A number of recent studies have highlighted the key role

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