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br Role of dysfunctional telomeres
2019-04-17
Role of dysfunctional telomeres in activation of p38 MAPK pathway as response to genotoxic stress Telomeres are unique structures at the ends of chromosomes that are located adjacent to more gene rich sub-telomeric regions and comprised of tandem GT-rich repeats, (TTAGGG)n in humans and other ver
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The OptiVol Fluid Index OVFI which
2019-04-17
The OptiVol Fluid Index (OVFI), which is derived from changes in intrathoracic impedance, can effectively assess HF by analyzing the changes in the intrathoracic impedance detected by the original OptiVol algorithm. Small et al. previously determined that a frequent and extended threshold crossing T
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As found in the previous study miR was
2019-04-17
As found in the previous study, miR-101 was significantly downregulated in CCA tumors compared with adjacent non-tumor tissues and this was supported by work from another group. This publication also found that miR-101 hepatic levels were decreased in CCA tumors compared with adjacent non-tumor tiss
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Cell adhesion to extracellular matrix requires
2019-04-16
Cell adhesion to extracellular matrix requires the interaction of different molecules like selectins, cadherins and integrins [21]. Especially αvβ3 integrin has been proposed to mediate the adhesion of malignant cells in different entities such as multiple myeloma and breast cancer [22,23]. Upon exp
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Los paradigmas de cosmopolitismo de Mito entraron en
2019-04-16
Los paradigmas de cosmopolitismo de Mito entraron en diálogo con los de Jorge Luis Borges, Octavio Paz, Baldomero Sanín Cano y Alfonso Reyes; todos integraron su comité de patrocinio. Se miró atentamente la actualidad cultural de París, pero no la de la nrf, sino la que concentró Les Temps Modernes
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In our opinion environmental pollution should be considered
2019-04-16
In our opinion, environmental pollution should be considered as a common risk factor for both dementia and schizophrenia. Studies are warranted to test this hypothesis, and if confirmed, the clinical implications could be of great importance for public and mental health. Future research, including l
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Heat shock facilitates the folding of various
2019-04-16
Heat shock facilitates the folding of various proteins as mediated by the HSP family and can stabilize mutant proteins. HS has been reported to facilitate maturation of WT-HERG as well as mutant HERG by activating the HSF family [15]. HSF-1, 2, and 4 were reported to be expressed in humans. HSF-1 is
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Introduction Atrial fibrillation AF is the
2019-04-16
Introduction Atrial fibrillation (AF) is the most common cardiac arrhythmia, and it commonly occurs after cardiac surgery. AF is often associated with stroke, congestive heart failure, and myocardial infarction, all of which contribute to the increase in the length of hospital stay, higher medical
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toll like receptor Los muy adeptos Fouchet y Joffroy publica
2019-04-16
Los muy adeptos Fouchet y Joffroy publican sus artículos al calor de la impactante edición francesa de Gallimard, segunda en aparecer (Aub, 1961). Que Aub lograse colocar su obra en el catálogo del sello más importante de Francia se debe, más que al regular contacto con su lugar de nacimiento, toll
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De todas maneras no escapa a la tem tica de
2019-04-16
De todas maneras no escapa a la temática de este trabajo la intuición de un contradictorio hecho: de que en este intento de interpretación de estos dos polémicos capítulos de Paradiso, dionisíacos, lo que estamos haciendo es, una vez más, buscar la sistematización iluminista, apolínea, a la que el m
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Es as como se establece
2019-04-16
Es así como se establece la relación entre los dos relatos: la novela histórica es parte de la novela policíaca y ambas tienden al mismo fin trágico, la muerte de su respectivo héroe. Al respecto, conviene hacer ciertas acotaciones sobre el término de “héroe”. Si bien en este último pasaje citado de
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apexbio dilution cost Hereditary syndromes with increased ri
2019-04-15
Hereditary syndromes with increased risk for gastric cancer include: 1) hereditary diffuse gastric cancer, 2) Lynch syndrome/hereditary non-polyposis colorectal cancer, 3) juvenile polyposis syndrome, 4) Peutz-Jeghers syndrome and 5) familial adenomatous polyposis. Hereditary diffuse gastric cancer
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Limitations of meta analyses are often based on
2019-04-15
Limitations of meta-analyses are often based on the strength of the data available. Only 26% of the eligible studies were judged to be at low risk of overall bias in this analysis. Other studies may have been at low risk for bias but failed to report information necessary for this determination. All
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Sin embargo la mayor a de los aventureros
2019-04-15
Sin embargo, la mayoría de los aventureros se quedó en la ensoñación, pues no logró hacerse de caudales, ni alcanzó encomiendas; de hecho, hacia 1540 y aun años después, el número de encomenderos en el gran Perú (hoy Perú, Bolivia y Ecuador) jamás rebasó los 500, indudablemente una minoría de la pob
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Two other groups subsequently published further data
2019-04-15
Two other groups subsequently published further data on iPSCs models of ARVC that have improved our understanding of this disease. Kim et al. developed iPSC models using episomal methods from 2 ARVC patients, as well as with PKP2 mutations . Detailed electrophysiological characterization of mutant
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