• Numerous clinical trials phase II and phase III have

  2019-04-30

  

  Numerous clinical trials (phase II and phase III) have been then designed to evaluate the efficacy of denosumab in oncology mainly in breast and prostate bone metastases (Table 1). These studies revealed that denosumab reduced significantly bone turnover markers similarly to osteoporotic patients. M

• The conventional cutoff for small for gestational age is bas

  2019-04-30

  

  The conventional cutoff for small for gestational age is based on birthweight, which is suitable for infants born at term but is far less appropriate for those born preterm. Preterm birth is itself pathological, and ultrasound-based estimates of fetal weight show that infants born preterm are much s

• Since the Food Safety Standards

  2019-04-30

  

  Since 2006, the Food Safety Standards Authority of India has led efforts to promote food safety, tighten food laws, and harmonise these laws with international standards and quality-management systems. These efforts need to be complemented with interventions focused on practices at the household lev

• br Tara Mangal and colleagues document the struggle

  2019-04-30

  

  Tara Mangal and colleagues document the struggle to eliminate polio in northern Nigeria. However, they overlook the importance of routine immunisation to polio eradication efforts. The investigators identified an association between the risk of contracting polio and oral polio vaccine unavailabil

• Cuando Gonzalo Pizarro se alz en el Per nunca mostr

  2019-04-30

  

  Cuando Gonzalo Pizarro se alzó en el Perú, nunca mostró intenciones de romper los vínculos que lo unían RPC1063 su rey, por mucho que su plan fuese establecer una monarquía, autónoma de la castellana, que gobernaría el territorio. En las misivas que envió al monarca, Pizarro confirmaba su obediencia

• In conclusion describing a single

  2019-04-30

  

  In conclusion, describing a single case observation of a PV-patient we have for the first time delivered the “proof of concept” that combination therapy with Rux and “low-dose” IFN is safe, tolerable and highly efficacious in PV, as evidenced by a rapid reduction in the JAK2V617F-allele burden in co

• Perhaps the greatest challenge however relates to the epidem

  2019-04-30

  

  Perhaps the greatest challenge however, relates to the epidemiology of this disease and understanding the interactions that occur between the reservoir hosts (ie, monkeys), vectors, and human activities that enable transmission. Understanding these complex behavioral and ecological interactions will

• Although SCN A variants account for of BrS SCN

  2019-04-29

  

  Although SCN5A variants account for 18–28% of BrS [196], SCN5A genetic testing is complicated by an approximately 3–5% “benign” variant frequency in the general population [194]. Therefore, even in the most common genetic cause of BrS, 1 in 10 “positive” tests could be a “false- positive” even if fo

• Los cl rigos que lograban hacerse de algunos

  2019-04-29

  

  Los clérigos que lograban hacerse de algunos medios movían su dinero continuamente buy olda través de préstamos, inversiones en bienes raíces o en ganado, y también se convertían en socios de compañías mercantiles y de otras empresas. La situación se facilitaba por los vínculos y redes que forjaban

• br En hab a un buen

  2019-04-29

  

  En 1950 había un buen número de publicaciones culturales circulando por Latinoamérica. Entre ellas sobresalían dos, que fueron paradigmáticas para la tradición literaria por su particular apuesta universalista: Sur —que se publicó regularmente en Buenos Aires entre 1931 y 1970— y Orígenes —que vio

• Presence of trisomy raises the possibility of added gene dos

  2019-04-29

  

  Presence of trisomy raises the possibility of added gene dose contributing to the leukemogenic process. The oncogene, c-kit, is localized to chromosome 4. Leukemic blasts of our patient strongly expressed c-kit. c-Kit expression was not studied in the other 4 reported cases of MPAL. Increased expres

• br Future perspectives Identification of LOX as a

  2019-04-29

  

  Future perspectives Identification of LOX as a modulator of the ECM to form pre-metastatic niches and subsequently bone metastasis arose as we were investigating the hypoxia tumour secretome using existing patient cohort data and cutting edge proteomics. Although condoned by some researchers as “

• plk1 inhibitor No obstante no se puede reducir a ning n

  2019-04-29

  

  No obstante, no se puede reducir plk1 inhibitor ningún género específico. Debido a los múltiples puentes que el libro extiende, y todos al mismo tiempo, representa una obra limítrofe. Es un texto que siempre apunta hacia algo más: está la prosa y el poema, además de la poesía y la poética. Hugo

• In this issue of James Platts Mills and colleagues describe

  2019-04-29

  

  In this issue of , James Platts-Mills and colleagues describe causes of diarrhoeal illness in the Mal-ED study. By contrast with GEMS, which sought to characterise the diarrhoeal episodes most likely to contribute to childhood mortality—that is, moderate-to-severe diarrhoeal disease in children seek

• As revolu es cubana e

  2019-04-29

  

  As revoluções cubana e sandinista foram dois dos assuntos mais discutidos na revista, com clara posição favorável aos revolucionários, em oposição às ditaduras anteriores de Fulgencio Batista, em Cuba, e dos Somoza, na Nicarágua. Tal posicionamento político não poderia ter sido outro, em virtude do

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