• br Results br Discussion We previously showed

  2018-11-08

  

  Results Discussion We previously showed that metformin treatment enhances murine adult neurogenesis in vivo without depleting the endogenous NPC pool (Wang et al., 2012). This finding has led to studies to repurpose metformin as a neuroregenerative agent to treat the injured or degenerating D6

• br Results br Discussion Different

  2018-11-08

  

  Results Discussion Different routes of reprogramming have been described even when starting with MEFs but these are restricted to late stages of reprogramming and have been demonstrated with different combinations of reprogramming factors (Parchem et al., 2014). Interestingly, recent reports a

• At a global level the analysis of DNA methylation profiles

  2018-11-08

  

  At a global level, the analysis of DNA-methylation profiles provides important insights into molecular and cell growth characteristics of PSC that would otherwise be difficult to identify. Reprogramming-associated variations in X-linked CpG methylation is of particular interest because of the comple

• Finally we recognize that rodent models for intranasal deliv

  2018-11-07

  

  Finally, we recognize that rodent models for intranasal delivery of NSCs have intrinsic limitations, such as the relative size and anatomical differences in the nasal and olfactory systems between humans and mice. Despite differences in the anatomy of the nasal cavity, larynx, and pharyngeal details

• br Results Among the analytic sample

  2018-11-07

  

  Results Among the analytic sample, 71,290 reported no prior military service and 10,115 reported some prior military service. The distribution of demographic characteristics by prior military service is presented in Table 1. Compared to those with prior military service, a greater percentage of t

• br Limitations and strengths There are several limitations t

  2018-11-07

  

  Limitations and strengths There are several limitations to our study. First, sleep-related problems were subjectively measured; therefore, some misclassifications might have occurred. Nonetheless, questions about self-reported sleep problems for timing and duration have demonstrated good validity

• The BET inhibitors thus far developed

  2018-11-07

  

  The BET inhibitors thus far developed are not selective within the BET family. JQ1(+) is highly specific to the BET family but binds to the bromodomains of all family members with similar affinities (Baud et al., 2014). Although we cannot rule out possible contributions of BRD2 and BRD3, our data po

• Although plasmin generation is increased acutely and to a

  2018-11-07

  

  Although plasmin generation is increased acutely and to a lesser extent, chronically, in patients with thrombotic disorders (Wada et al., 1989), the role of plasmin in complement-mediated events during thrombus formation, propagation, and resolution is unknown. Our finding that plasmin drives C5a ge

• RHC 80267 The following are the supplementary data

  2018-11-07

  

  The following are the supplementary data related to this article. Funding Sources This work is funded by the Medical Research Council (H8RSRS00), Ovarian Cancer Action (HER00070), the Oxford Biomedical Research Centre, the National Institute for Health Research (HJRWAC05) and the Experimental Ca

• It is technically challenging to extract

  2018-11-07

  

  It is technically challenging to extract proteins of interest from bone due to the abundance of collagens and minerals. A pilot study using HCl/Urea extraction identified 119 proteins in OA subchondral bone with only 7 proteins shared between the low and high damage regions. This data suggests that

• Gametocyte carriage has been an efficacy

  2018-11-07

  

  Gametocyte carriage has been an efficacy end point in antimalarial drug studies but it is crucial to realise that gametocytaemia is a weak surrogate marker of mosquito infectivity. Gametocyte density has been shown to correlate with mosquito infectivity in untreated individuals in a non-linear relat

• MITF has previously been described as having both oncogenic

  2018-11-07

  

  MITF has previously been described as having both oncogenic and tumour suppressor properties within melanoma (Hartman and Czyz, 2015; Levy et al., 2006). This idea is further perpetuated by the fact that while BRN2 and MITF have been shown to be expressed in two mutually exclusive populations, BRN2

• br Funding The work was financially supported by

  2018-11-07

  

  Funding The work was financially supported by the by grants from the Ministry of Science and Technology of the People\'s Republic of China (2014AA020524), the Special Research Fund of Ministry of Health for Non-Profit Sector (201302010), the National Nature Science Foundation (81302507), the Sci

• br Type Interferonopathies and Link to T D br Type

  2018-11-07

  

  Type 1 Interferonopathies and Link to T1D Type I IFNs and Type 1 IFN-Opathies: Implications for T cell Responses? As previously mentioned, T1D is historically characterized as a T-cell mediated disease. Here, we extend our discussions to suggest that the established IFN response that precedes

• br Experimental design materials and methods The synthesis w

  2018-11-07

  

  Experimental design, materials and methods The synthesis was carried out as described previously [1]. “Krokodil extract” samples were obtained by the treatment of 4mL of crude “krokodil” with NaOH 20% (m/v) until alkalization, followed by extraction with ethyl acetate. The organic phases were gat

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