• In this study Oncomine GEO and TCGA databases were

  2019-12-11

  

  In this study, Oncomine, GEO and TCGA databases were used to analyze the expression of UBE2S gene in HCC and normal liver tissues to determine the relationship between UBE2S expression and prognosis of hepatocellular carcinoma. The potential function of UBE2S in HCC was analyzed by screening UBE2S c

• Although many GPCR heteromers have been identified using

  2019-12-11

  

  Although many GPCR heteromers have been identified using heterologous cell lines, only very few fit all three criteria. This is mainly due to the difficulties to study these structures in native tissues because of the lack of sensitive and selective tools, not only capable of detecting in vivo evide

• The DDR gene located on

  2019-12-11

  

  The DDR1 gene, located on chromosome region 6p21.33, encodes a transmembrane tyrosine kinase receptor involved in melanocyte anchoring through binding to collagen IV (Silva de Castro et al., 2010). So far, only three studies have been conducted on the association between DDR1 polymorphism and the ri

• In contrast irinotecan has shown much less

  2019-12-11

  

  In contrast, irinotecan has shown much less myelosuppression and may be more active in Ewing sarcoma both alone and in combination with temozolamide. One phase II study of 13 heavily pretreated Ewing sarcoma patients demonstrated a response rate of 38% including 2 complete responses (Bisogno et al.,

• Introduction Excessive exposure to ultraviolet UV

  2019-12-10

  

  Introduction Excessive exposure to ultraviolet (UV) irradiation from the sun injures human skin, which might lead to premature aging and skin pathologies [1], [2]. Chronic exposure to UV (especially ultraviolet-B, UVB) irradiation could profoundly affect the skin epidermis, interfering with the ker

• In order to assess quantitatively

  2019-12-10

  

  In order to assess quantitatively the contribution of the ung, dug and dut (-)-Lobeline hydrochloride to uracil-DNA accumulation in E. coli, we have developed a novel method for measuring uracil residues in DNA that is based on the approach of Kow and co-workers [33] for measuring AP-sites in DNA. T

• It is not precisely known which of the intramolecular intera

  2019-12-10

  

  It is not precisely known which of the intramolecular interactions created by the SH2 domain, the SH3–SH2 linker and the SH2–kinase linker are essential for the catalytic activity of Csk or how these interactions regulate Csk activity. Thus far it has been shown that site-directed mutagenesis of SH3

• Although it remains an unsettled issue

  2019-12-10

  

  Although it remains an unsettled issue, evidence favors that the endothelin ETA ru listings sale may play a more important pathological role. While both endothelin ETA and ETB receptors are found in most tissues, endothelin ETA receptor is the predominant receptor responsible for the vasoconstricti

• The use of recombinant ER and ER binding assays

  2019-12-10

  

  The use of recombinant ERα and ERβ binding assays offers a relatively inexpensive, rapid technique for screening compounds for potential direct BIBR-1048 australia receptor modulatory activity and understanding the mechanisms of existing herbal medicines. For background on the protein production sys

• 961 The idea of boron based pro estrogens has been utilized

  2019-12-10

  

  The idea of boron-based pro-estrogens has been utilized before; in previous studies, the selective estrogen receptor modulators (SERMs) tamoxifen and endoxifen have been masked as boronate esters.13, 14, 15 Tamoxifen and endoxifen both target ERα as therapies for breast cancer. The previous work foc

• Mohan et al found no improvement of the strength of

  2019-12-09

  

  Mohan et al. [8] found no improvement of the strength of the bricks due to addition of waste RHA. Hossain et al. [9] collected RHA from a local rice mill, where rice husk was burnt in an uncontrolled environment, and then used for replacement of clay in brick production. With inclusion of RHA water

• Primary renal PNET was first reported by Seemayer et al

  2019-12-09

  

  Primary renal PNET was first reported by Seemayer et al in 1975. The possible etiology of rPNET is based on the theory of neural cell intussusception in the kidney during development that initiates the tumorigenesis. rPNET most commonly affects young adults, with a mean age of 30.4 years and male pr

• SU6656 Related with the studies by Zizza et

  2019-12-09

  

  Related with the studies by Zizza et al. described above [66], work by Ward et al. [68] suggested that the C2 domain of cPLA2α, which binds to zwitterionic membranes with high affinity in a Ca2+-dependent manner, has a high membrane remodeling activity, producing dramatic changes in membrane curvatu

• Numerous studies have investigated the contribution of

  2019-12-09

  

  Numerous studies have investigated the contribution of N-cadherin to metastasis and tumorigenesis. The overexpression of N-cadherin has been shown to enhance tumor invasion and motility in multiple cancer models [25,40,48]. Transforming growth factor beta 1 (TGFβ1) is a strong EMT inducer. In fact,

• Studies of LRRK tagged with green fluorescent protein

  2019-12-09

  

  Studies of LRRK2 tagged with green fluorescent protein revealed the presence of monomeric LRRK2 in the NVP-BSK805 of living cells, while LRRK2 oligomers were found in the proximity of the plasma membrane, suggesting that both oligomerization status and compartmentalization of LRRK2 defines its func

15703 records 895/1047 page Previous Next First page 上5页 891892893894895 下5页 Last page