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AQP protein expression was determined by
2021-04-17
AQP4 protein expression was determined by Western blot analysis. Briefly, protein samples (50μg) from brains or astrocytes were separated by 12% SDS–polyacrylamide gel electrophoresis and transferred to nitrocellulose membranes. The membranes were reacted with a rabbit polyclonal antibody against AQ
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As compared with the broad spectrum of chemicals
2021-04-17
As compared with the broad spectrum of chemicals known to serve as the ligands for PXR and CAR, the ligands of VDR are previously restricted to VD3 as well as its hydroxylated metabolites and the secondary bile BOP reagent receptor LCA. Recently, the VDR-binding capacities of more compounds have bee
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Regarding the effects of CRF on
2021-04-17
Regarding the effects of CRF on anxiety, Sahuque et al. (2006) have demonstrated that this neuropeptide also enhances anxiety when injected into the bed nucleus of the stria terminalis (BNST), a MK-4827 hydrochloride structure that has also been related to defensive behavior (Casada and Dafny, 1991
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br Acknowledgments We would like
2021-04-17
Acknowledgments We would like to thank the Bloomington Stock Center and the Vienna Drosophila RNAi Center for stocks used in this study. RMG was supported in part by a Professors grant to R. Losick from the HHMI and this work was supported by NSF grant 074578 to A.A.N. Introduction The catabo
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br Disclosure and conflicts of interest br
2021-04-16
Disclosure and conflicts of interest Acknowledgements This research was supported by grant (BT/PR/11293/BRB/10/849/2008) from Department of Biotechnology (DBT), Government of India and a DST YOS Chair Professorship to PB. The mass spectrometry facility is supported by an institutional program
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AM 281 australia Exogenous administration of POCs could theo
2021-04-16
Exogenous administration of POCs could theoretically inhibit breastfeeding [69]; however, the evidence in this review does not generally support a negative impact on breastfeeding outcomes. Studies examining the AM 281 australia of POCs among postpartum women overall demonstrated no adverse effects
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Mohan et al found no improvement of the strength
2021-04-16
Mohan et al. [8] found no improvement of the strength of the bricks due to addition of waste RHA. Hossain et al. [9] collected RHA from a local rice mill, where rice husk was burnt in an uncontrolled environment, and then used for replacement of clay in brick production. With inclusion of RHA water
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There has recently been some interest
2021-04-16
There has recently been some interest in Uba6, which is most similar to slime mold, with BLAST identities of 59% and positives 73% in the 400–600 ADD range. The 400–600 ADD correlation of the two profiles is a striking 87%, so functional differences probably arise outside the ADD binding domain. Hu
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br Conclusions We can conclude that Arg
2021-04-16
Conclusions We can conclude that Arg293 is important but not indispensable for MeGlcA recognition by EcXyn30A since the R293A variant still retains activity and preference for MeGlcA-substituted substrates. The substrate specificity of GH30_8 glucuronoxylanases is most probably determined by an o
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Recoverin is a kDa retinal protein that binds to calcium
2021-04-16
Recoverin is a 23-kDa retinal protein that binds to calcium. It regulates the spleen tyrosine kinase of rhodopsin during visual transduction within photoreceptor cells. Since the pathogenicity of anti-recoverin antibody is potent, anti-recoverin CAR patients often have progressive visual impairment
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br Ubiquitin Capture by the
2021-04-16
Ubiquitin Capture by the Mobile APC11 RING Domain Contributes to Processive Substrate Ubiquitylation Although the rules of Ub-mediated proteolysis are only beginning to emerge, the rate and order in which different APC/C substrates are degraded during the Pimasertib correlates with processivity
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A previous report demonstrated that
2021-04-16
A previous report demonstrated that DA-dependent oxidative stress may be the initial event in MA neurotoxicity (Cubells et al., 1994). Oxidative burdens at early stage might be a prerequisite for neurotoxic scenarios induced by 3-FMA, and they are in line with MA case (Shin et al., 2012, Shin et al.
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bafilomycin a1 Furthermore Survivin is a member of the inhib
2021-04-16
Furthermore, Survivin is a member of the inhibitor of apoptosis family. IR induces a rapid nuclear accumulation of survivin and subsequent phosphorylation of the protein in the nucleus. Co-immunoprecipitation and immunofluorescence co-localization analyses revealed an interaction among survivin, Ku7
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naphthalimide a well known DNA intercalator
2021-04-16
1,8-naphthalimide, a well-known DNA intercalator, has been extensively investigated in the development of antitumor agents [10]. Some of the naphthalimide derivatives, such as amonafide, elinafide and bisnafide (Fig. 1), have entered into phase II clinical trials stage [10]b), [11]. Among them, elin
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This project was funded by the Deutsche Forschungsgemeinscha
2021-04-16
This project was funded by the Deutsche Forschungsgemeinschaft within FOR 2251 (project grants EB 285/2-1 and WI 3272/3-1) and in part by additional contributions from the Bundesministerium für Bildung und Forschung (D.I.S award Nos. BIOSCAT [05K12YE1]) and the Horizon 2020 programme of the European
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