• The neurobiological mechanisms underlying DHK induced NOR

  2022-08-10

  

  The neurobiological mechanisms underlying DHK-induced NOR learning and memory impairments remain unclear. Accumulated evidence shows that astrocyte-neuron lactate shuttle is of crucial important in synaptic plasticity and memory formation, and regulation of neuronal gene expression related to synapt

• The development of immobilization techniques for glucosidase

  2022-08-10

  

  The development of immobilization techniques for β-glucosidase offers a potential way to enable its reuse several times [13]. The aim of immobilization is to trap the enzyme within or on the surface of an insoluble material with retention of its catalytic activity [14]. The immobilization strategy a

• br Introduction Maintaining blood glucose within an appropri

  2022-08-10

  

  Introduction Maintaining blood glucose within an appropriate range is crucial for survival. In diabetes, those who suffer episodes of severe hypoglycemia have an increased risk of death [1], [2]. The cki is especially dependent on an adequate, continuous supply of circulating glucose to fuel meta

• In mammals the primary cilium

  2022-08-10

  

  In mammals, the primary cilium is considered a hub for signal transduction. The cilium has previous been associated with transduction of several pathways including Wnt (Corbit et al., 2008, McDermott et al., 2010, Tran et al., 2014), PDGF (Clement et al., 2013, Schneider et al., 2010, Schneider et a

• The current gold standard for diagnosing BAM or BAD

  2022-08-10

  

  The current gold standard for diagnosing BAM or BAD is the measurement of BA turnover rate with radiolabelled tauroselcholic (75selenium) Betamethasone Dipropionate (also known as the SeHCAT retention test). SeHCAT test involves the use of a synthetic analogue of naturally occurring conjugated tauro

• On the contrary the benzhydrol series showed modest activity

  2022-08-10

  

  On the contrary, the benzhydrol series showed modest activity with EC of two digit micromole. The bulkiness of the Actinomycin D tail may be the reason for the low activity. Interestingly, introduction of H-bonding groups, such as OMe in and CF in , slightly improved the activity compared to the u

• There were limitations to this study Specifically

  2022-08-09

  

  There were limitations to this study. Specifically, although rigorously examined for accuracy, the NCDB and SEER databases still suffer from issues with data entry and completeness of the treatment record. Of note, although the data were collected on a modern cohort of patients treated from 2010 to

• Dopamine HCl sale br Conclusion and future perspectives In

  2022-08-09

  

  Conclusion and future perspectives In the setting of myocardial I/R stress, HDAC activity is induced and contributes to myocardial injury. HDAC inhibition appears to protect the Dopamine HCl sale from I/R injury by activating a variety of pro-survival molecular pathways. From a clinical relevanc

• The balance and composition of the gut microflora can be

  2022-08-09

  

  The balance and composition of the gut microflora can be altered by the use of antibiotics or by colonization of the intestine by pathogens. This change may also induce, or be induced by, modifications in the body’s immune response, ultimately leading to disease. Thus, when intestinal homeostasis is

• br Conclusion The following is the supplementary data

  2022-08-09

  

  Conclusion The following is the supplementary data related to this article. Conflict of interest Funding Acknowledgements Peroxiredoxin VI (Prdx6) is a dual-functioning antioxidant enzyme that acts to protect biological membranes against damage caused by lipid peroxidation , . The enz

• br Introduction br Mitochondrial dysfunction and cancer

  2022-08-09

  

  Introduction Mitochondrial dysfunction and cancer Lactate and succinate as oncometabolites Intracellular actions of lactate and succinate as tumor promoters Cell-surface receptors for lactate and succinate and their role in cancer GPR109A as the receptor for butyrate and β-hydroxybu

• In addition to gonadotropes GnRHRs have

  2022-08-09

  

  In addition to gonadotropes, GnRHRs have also been detected on somatotropes, lactotropes, thyrotropes, melanotropes, somatolactin (SL) cells, and/or corticotropes using immunohistochemical, radioligand-binding, or mRNA expression approaches across species; including fishes, rats, and humans (La Rosa

• With the advent of genome sequencing hexokinase gene sequenc

  2022-08-09

  

  With the advent of genome sequencing, hexokinase gene sequences are now available from a far greater number of vertebrate species, as well as from diverse non-vertebrate animal species. As indicated above, searches of vertebrate genome sequences revealed the existence of a novel fifth member of the

• More recently Dal Peraro and coworkers carried out s CG

  2022-08-09

  

  More recently, Dal Peraro and coworkers [38] carried out 4 μs CG MD simulations of GS with six randomly placed C9915-55 peptides embedded into a synaptic plasma bilayer model. This lipid raft model was constituted by 32 different pp2 and cholesterol (54.74%). In this study, the authors observed a h

• br The bile acid farnesoid X receptor

  2022-08-08

  

  The “bile acid” farnesoid X receptor (FXR) The Farnesoid X Receptor (FXR) is a ligand-activated nuclear receptor belonging to the Nuclear Receptor superfamily of transcription factors exploiting various crucial functions in mammalian physiology, including reproduction, development and metabolism

16426 records 418/1096 page Previous Next First page 上5页 416417418419420 下5页 Last page