A recently developed gene editing technology using

2018-10-20

A recently developed gene-editing technology using RNA-guided endonuclease (Gaj et al., 2013), which allows the desired gene to be inserted into a genomic safe harbor (GSH) area (Papapetrou et al., 2011), should be considered to avoid undesirable random genomic insertion of EOS-C(3+)-KR in the gener

br Results Our previous work showed

2018-10-20

Results Our previous work showed that severe bacterial sepsis induced by P. aeruginosa or by its LPS causes a TLR4-dependent dysfunctional expansion of HSC and hematopoietic progenitor interleukin 2 receptor (HSPC) (Rodriguez et al., 2009). To determine whether these changes are MYD88 or TRIF de

br Results To investigate the molecular and

2018-10-20

Results To investigate the molecular and cellular phenotypes perturbed in DS, we compared DS and normal ESCs and their neural derivatives. In the past, we have isolated three DS-ESC lines, namely CSES13, CSES20, and CSES21, from PGS-derived embryos with trisomy of chromosome 21 (Figure 1A) (Bianc

In the present study we aimed to establish a combination

2018-10-20

In the present study, we aimed to establish a combination therapy approach composed of cellular replacement by ESC-derived neural progenitors linked to BDNF supply. For this reason, we have generated BDNF-overexpressing mouse ESCs by knockin technology that display an enhanced neuronal and GABAergic

Accumulating evidence has demonstrated that cancer

2018-10-20

Accumulating evidence has demonstrated that cancer cells are able to activate the autologous complement system (Cho et al., 2014; Fishelson, 2003; Matsumoto et al., 1997; Niculescu et al., 1992). To evade complement destruction, tumor cells upregulate mCRPs, and CD59 is the most relevant among the t

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2018-07-29