• Cancer cells use epigenetic mechanisms to control

  2018-10-24

  

  Cancer 5-aminolevulinic acid use epigenetic mechanisms to control tumor growth, invasion, and resistance to therapy. Novel therapeutic approaches targeting epigenetic modifications are considered the new frontier in cancer therapy. In fact, pharmacological modulation of epigenetic alterations is ex

• Cryopreserved peripheral blood mononuclear cells PBMC from t

  2018-10-24

  

  Cryopreserved peripheral blood mononuclear cells (PBMC) from this patient were used for the generation of an induced pluripotent stem cell (iPSC) that harbour a “highest risk” RET mutation according to ATA guidelines, i.e. a 2753T>C missense de novo mutation at exon 16 leading to the most frequent

• In previous tumor studies we have

  2018-10-24

  

  In previous tumor studies, we have used a p53-null syngeneic mouse model to mimic p53 loss of function in human breast cancer. This model was developed by transplanting p53-null mammary epithelium into the cleared mammary fat pads of wild-type, syngeneic Balb/c-recipient mice, resulting in spontaneo

• CSCs of breast tumors are commonly enriched by combinations

  2018-10-24

  

  CSCs of breast tumors are commonly enriched by combinations of several cell-surface antigens, such as CD44/CD24/EPCAM (Al-Hajj et al., 2003), or by high ALDH (aldehyde dehydrogenase) activity (Ginestier et al., 2007). However, existing markers lack specificity, also reflective of a substantial propo

• In order to understand how hematopoiesis

  2018-10-24

  

  In order to understand how hematopoiesis is regulated, it is necessary not only to understand the different signals emanating from the niche (Anthony and Link, 2014), but also to comprehend the integration of these signals by HSCs. Canonical Wnt signaling has been related to the regulation of HSCs

• Zscan is sometimes considered as

  2018-10-24

  

  Zscan4 is sometimes considered as a marker of highly pluripotent status, merely due to its expression at the two-cell stage during development (Cerulo et al., 2014). However, based on our observation, we would like to propose that the expression of Zscan4 is activated in response to telomere shorten

• eukaryotic initiation factor br Results br Discussion In the

  2018-10-24

  

  Results Discussion In the meibomian gland, low numbers of LRCs were observed after 28, 42, and 56 days of chase, which fulfill the slow-cycling, undifferentiated, and low population criteria of adult epithelial stem eukaryotic initiation factor characterized in other tissues (Alonso and Fuchs

• Mitochondria are highly dynamic organelles

  2018-10-24

  

  Mitochondria are highly dynamic organelles with complex structures involved in multiple processes, including energy metabolism, reactive oxygen species (ROS) generation, mitochondrial dynamics and distribution, and the induction of apoptosis. A number of recent studies have highlighted the key role

• br Objects and methods of study The

  2018-10-24

  

  Objects and methods of study The PE samples were acted upon two types of effects: The angular shift of (002) reflection patterns to smaller angles was recorded upon elastic tensile stress at T = 90 K by X-ray diffractometry. The increase of the distance between the skeletal carbon atoms along

• The sorptive and mechanical properties of the samples

  2018-10-24

  

  The sorptive and mechanical properties of the samples we have examined are listed in Table 3. Unmodified samples of high-silica rocks are characterized by significantly lower values of the maximum sorption space volume than the corresponding values for low-silica samples (both in water and in benze

• br Methods br Measures br

  2018-10-24

  

  Methods Measures Statistical analyses Data analysis was conducted at the [blinded] Research Data Centre using STATA statistical software (version 14) (Statacorp, College Station, TX, 2015). Marginal effect glut1 analyses were calculated to quantify the potential reduction in adverse menta

• thorough The GMM Difference estimator also

  2018-10-23

  

  The GMM Difference estimator – also known as the Arellano–Bond estimator – seeks to address the problem of endogeneity with the technique of instrumental variables. This methodology suggests the estimation in two steps. The problem encountered in GMM Difference is that in most cases the error term

• Strengths of this analysis include that the

  2018-10-23

  

  Strengths of this analysis include that the biomarker assay was analytically validated, the data were from a randomized clinical trial, and the hypothesis was prospectively stated prior to data unblinding (Khleif et al., 2010). The fact that a single biomarker was identified minimized the potential

• br Author Contributions br Acknowledgments This

  2018-10-23

  

  Author Contributions Acknowledgments This work was supported in part by the Canadian Institutes of Health Research (a grant to Q.B.L, #105218, and a New Investigator Award to Q.B.L), the Ontario Ministry of Research and Innovation (an Early Researcher Award to Q.B.L, #112621), and Natural Scie

• actin polymerization inhibitor In this issue of Ezzikouri et

  2018-10-23

  

  In this issue of , Ezzikouri et al. reported on the use of a novel serum marker, 3β-hydroxysterol Δ24-reductase auto-antibody (DHCR24 Ab), as a surrogate marker to indicate progression from chronic hepatitis C to HCC (). By evaluating serum levels of the antibody in patients with different stages of

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