• In general elderly who represent the fastest

  2018-11-09

  

  In general, elderly, who represent the fastest growing population, have been shown to be particularly susceptible to burn injuries (Pham et al., 2009). This is due to thinning skin, decreased sensations, mental alterations, or other contributing factors (Pham et al., 2009; Gerstein et al., 1993). T

• Similar as the rRBD protein of SARS

  2018-11-09

  

  Similar as the rRBD protein of SARS-CoV which induced high titres of protective anti-RBD antibody responses in NHPs (Wang et al., 2012), the rRBD vaccination of MERS-CoV induced effective IgG and neutralisation factor xa inhibitor in our rhesus macaque model. Besides, the induced IgG and neutralisa

• Adult HSCs can be highly

  2018-11-08

  

  Adult HSCs can be highly purified (Purton and Scadden, 2007; Osawa et al., 1996). This is in contrast to the first HSCs found in the embryo, which have been more difficult to enrich thus far (Taoudi et al., 2005). Many markers currently used to isolate adult HSCs do not apply for embryonic HSCs. Mor

• In William Russell and Rex Burch classified humane animal

  2018-11-08

  

  In 1959, William Russell and Rex Burch classified humane animal experimental techniques under the headings of replacement, reduction, and refinement — now commonly known as the three Rs. Replacement means the complete substitution of a given animal experiment by one or several alternative tests that

• Acknowledgments We are indebted to the Citomics unit

  2018-11-08

  

  Acknowledgments We are indebted to the Citomics unit of the IDIBAPS for technical help. This work was supported by grants from the Spanish Ministry of Economia y CompetitividadBIO2011-30299-C02-02 and from CIDEM-Generalitat de CatalunyaVALTEC09-2-0047. and was developed at the Centro Esther Koplowi

• Subsequently we confirmed that the gene modified

  2018-11-08

  

  Subsequently, we confirmed that the gene modified clone of H256 C6, termed CHMP2B IVS5AS GG-CC, remained truly pluripotent. This was demonstrated via expression analyses of key pluripotency markers on protein level (Fig. 1B). Additionally, CHMP2B IVS5AS GG-CC retained the potential to differentiate

• A number of animal models of CLI including the hindlimb

  2018-11-08

  

  A number of animal models of CLI, including the hindlimb ischemia model after femoral artery ligation in rats (Rochester et al., 1994) and rabbits (Hao et al., 2014), have been proven useful to assess the effects of various cell types and to study potential mechanisms of action. For instance, IM inj

• br Experimental Procedures br Author

  2018-11-08

  

  Experimental Procedures Author Contributions Acknowledgments Introduction We recently described an animal model in which primary genetic lesions in bone marrow (BM) stromal dopamine-2 receptor antagonist resulted in abnormal hematopoiesis in mice and the rare development of acute leukemi

• Pathway analysis on these genes

  2018-11-08

  

  Pathway analysis on these genes identified their role in stem-cell-maintenance-related Wnt pathway (Baker, 2010), cell-cycle-related p53 pathway, JAK stat, and MAPK pathways in addition to others listed in Table S4. These results suggest a potential contribution of multiple signaling pathways for st

• br Experimental Procedures br Author Contributions br Acknow

  2018-11-08

  

  Experimental Procedures Author Contributions Acknowledgments Introduction Unlike the human prostate, which is organized into a single lobe with varying zonal layers, the murine prostate has four distinct lobes surrounding the urethra. The adult prostate contains three epithelial lineages

• br Introduction Chronic kidney diseases CKDs

  2018-11-08

  

  Introduction Chronic kidney diseases (CKDs) affects ∼10% of the population and represent a major global health burden (Eckardt et al., 2013). Worldwide, the number of patients with end-stage renal disease (ESRD) receiving renal replacement therapy is estimated at more than 1.4 million, with an an

• Because freshly isolated hepatocytes rapidly

  2018-11-08

  

  Because freshly isolated hepatocytes rapidly lose their functions, it is a major challenge to generate fully functional hepatocytes from pluripotent stem cells. While hepatocytes derived from CPM+ LPCs expressed high levels of metabolic activity, the levels of some proteins are not as high as primar

• br Results br Discussion We previously showed

  2018-11-08

  

  Results Discussion We previously showed that metformin treatment enhances murine adult neurogenesis in vivo without depleting the endogenous NPC pool (Wang et al., 2012). This finding has led to studies to repurpose metformin as a neuroregenerative agent to treat the injured or degenerating D6

• br Results br Discussion Different

  2018-11-08

  

  Results Discussion Different routes of reprogramming have been described even when starting with MEFs but these are restricted to late stages of reprogramming and have been demonstrated with different combinations of reprogramming factors (Parchem et al., 2014). Interestingly, recent reports a

• At a global level the analysis of DNA methylation profiles

  2018-11-08

  

  At a global level, the analysis of DNA-methylation profiles provides important insights into molecular and cell growth characteristics of PSC that would otherwise be difficult to identify. Reprogramming-associated variations in X-linked CpG methylation is of particular interest because of the comple

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