• Cuando Gonzalo Pizarro se alz en el Per nunca mostr

  2019-04-30

  

  Cuando Gonzalo Pizarro se alzó en el Perú, nunca mostró intenciones de romper los vínculos que lo unían RPC1063 su rey, por mucho que su plan fuese establecer una monarquía, autónoma de la castellana, que gobernaría el territorio. En las misivas que envió al monarca, Pizarro confirmaba su obediencia

• In conclusion describing a single

  2019-04-30

  

  In conclusion, describing a single case observation of a PV-patient we have for the first time delivered the “proof of concept” that combination therapy with Rux and “low-dose” IFN is safe, tolerable and highly efficacious in PV, as evidenced by a rapid reduction in the JAK2V617F-allele burden in co

• Perhaps the greatest challenge however relates to the epidem

  2019-04-30

  

  Perhaps the greatest challenge however, relates to the epidemiology of this disease and understanding the interactions that occur between the reservoir hosts (ie, monkeys), vectors, and human activities that enable transmission. Understanding these complex behavioral and ecological interactions will

• Although SCN A variants account for of BrS SCN

  2019-04-29

  

  Although SCN5A variants account for 18–28% of BrS [196], SCN5A genetic testing is complicated by an approximately 3–5% “benign” variant frequency in the general population [194]. Therefore, even in the most common genetic cause of BrS, 1 in 10 “positive” tests could be a “false- positive” even if fo

• Los cl rigos que lograban hacerse de algunos

  2019-04-29

  

  Los clérigos que lograban hacerse de algunos medios movían su dinero continuamente buy olda través de préstamos, inversiones en bienes raíces o en ganado, y también se convertían en socios de compañías mercantiles y de otras empresas. La situación se facilitaba por los vínculos y redes que forjaban

• br En hab a un buen

  2019-04-29

  

  En 1950 había un buen número de publicaciones culturales circulando por Latinoamérica. Entre ellas sobresalían dos, que fueron paradigmáticas para la tradición literaria por su particular apuesta universalista: Sur —que se publicó regularmente en Buenos Aires entre 1931 y 1970— y Orígenes —que vio

• Presence of trisomy raises the possibility of added gene dos

  2019-04-29

  

  Presence of trisomy raises the possibility of added gene dose contributing to the leukemogenic process. The oncogene, c-kit, is localized to chromosome 4. Leukemic blasts of our patient strongly expressed c-kit. c-Kit expression was not studied in the other 4 reported cases of MPAL. Increased expres

• br Future perspectives Identification of LOX as a

  2019-04-29

  

  Future perspectives Identification of LOX as a modulator of the ECM to form pre-metastatic niches and subsequently bone metastasis arose as we were investigating the hypoxia tumour secretome using existing patient cohort data and cutting edge proteomics. Although condoned by some researchers as “

• plk1 inhibitor No obstante no se puede reducir a ning n

  2019-04-29

  

  No obstante, no se puede reducir plk1 inhibitor ningún género específico. Debido a los múltiples puentes que el libro extiende, y todos al mismo tiempo, representa una obra limítrofe. Es un texto que siempre apunta hacia algo más: está la prosa y el poema, además de la poesía y la poética. Hugo

• In this issue of James Platts Mills and colleagues describe

  2019-04-29

  

  In this issue of , James Platts-Mills and colleagues describe causes of diarrhoeal illness in the Mal-ED study. By contrast with GEMS, which sought to characterise the diarrhoeal episodes most likely to contribute to childhood mortality—that is, moderate-to-severe diarrhoeal disease in children seek

• As revolu es cubana e

  2019-04-29

  

  As revoluções cubana e sandinista foram dois dos assuntos mais discutidos na revista, com clara posição favorável aos revolucionários, em oposição às ditaduras anteriores de Fulgencio Batista, em Cuba, e dos Somoza, na Nicarágua. Tal posicionamento político não poderia ter sido outro, em virtude do

• br Discussion This case report demonstrates for

  2019-04-29

  

  Discussion This case report demonstrates for the first time a remarkable hematological and molecular response with a marked sustained decrease in the JAK2-V617F allele burden during statin and bisphosphonate combination therapy of a patient with PV. Both agents potently inhibit the mevalonate pat

• br In Magaret E Kruk and colleagues examine

  2019-04-29

  

  In Magaret E Kruk and colleagues examine a very important aspect of maternal and newborn health that is poorly studied in low-income countries, namely quality of care. Poor quality of care has been a recurrent theme used to explain the prevailing high level of maternal and newborn morbidity and m

• Although two different types of survey were used DHS

  2019-04-29

  

  Although two different types of survey were used (DHS and MICS), datasets were revised to ensure that mmae indicators were uniformly compliant with international definitions. The CCI is restricted to coverage indicators that were standardised in the 1990s and for which definitions remained stable wi

• Introduction Verapamil sensitive idiopathic left

  2019-04-28

  

  Introduction Verapamil-sensitive idiopathic left ventricular tachycardia (ILVT) has been shown to be a clinical entity of left-sided idiopathic ventricular tachycardia (VT) [1,2]. In electrophysiological studies, two specific local potentials, the diastolic Purkinje (Pd) potential and presystolic P

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